Fenitoin je poznati induktor CYP3A4 izoenzima i ubrzava metabolizam diazepama u jetri. Smanjeno dejstvo diazepama. Diazepam deluje na metabolizam fenitoina na nepredvidiv način: metabolizam fenitoina pod dejstvom diazepama može biti ubrzan ili usporen, ili ostati nepromenjen.
Predloženi mehanizam interakcije je kompetitivno vezivanje teofilina za adenozinske receptore u mozgu. Na taj način onemogućava se farmakodinamsko dejstvo diazepama, dolazi do npr. smanjenja sedativnog i psihomotornog dejstva diazepama.
Kod oštećene funkcije bubrega ne dolazi do klinički značajne promene u poluvremenu eliminacije diazepama, tako da obično nije neophodno prilagođavanje doze.
Never acquire Co-codamol 30/500 Tablets If you're Expecting or Imagine you may be pregnant Except you have mentioned this using your prescriber and the benefits of cure are considered to outweigh the likely hurt on the infant.
If you will get any side effects, speak with your medical doctor or pharmacist. This features any achievable aspect effects not outlined During this leaflet. See part 4
Anterogradna amnezija se može javiti i pri primeni terapijskih doza, iako se naročito uočava pri primeni velikih doza. Ovo stanje se najčešće javlja nekoliko sati nakon primene leka i zbog toga, da bi se smanjio rizik, pacijent treba da ima 7-eight sati neprekidnog sna nakon primene leka (videti odeljak four.eight). Efekti amnezije mogu biti povezani sa neodgovarajućim ponašanjem.
It can take care of numerous brings about of delicate to average discomfort and comes in the shape of capsules, tablets and effervescent tablets. It really works successfully in eradicating quick-expression pains and aches including again pain.
Nije potvrđena bezbednost primene diazepama tokom trudnoće kod ljudi, niti read more postoje dokazi o neškodljivosti njegove primene iz studija na životinjama.
Epileptički standing, konvulzije nastale usled trovanja i febrilne konvulzije: Putem intravenske injekcije:
Codeine will not be suggested in little ones with respiratory problems, For the reason that symptoms of morphine toxicity can be even worse in these children.
Osobe koje pokazuju suicidalne tendencije ne smeju imati pristup većim količinama diazepama zbog rizika od predoziranja.
These remedies deal with problems dependant on which impact they bring about. While you'll find different kinds given that they have distinctive Key effects, there’s a lot of overlap in between them. One example is, most benzodiazepines Have got a sedative effect Along with their Key influence.
Sedative: This result has several makes use of. It may treat circumstances and signs and symptoms associated with muscle Regulate, for instance muscle mass spasms. It might also take care of additional severe concerns like catatonia (which regularly comes about with mental wellbeing circumstances like schizophrenia or bipolar disorder).
Sok od grejpfruta može povećati količinu diazepama u Vašoj krvi. Ukoliko ste bensedin 10 mg starijeg životnog doba, imate cirozu jetre ili bilo koje stanje navedeno u odeljku two, dejstvo leka Bensedin može biti pojačano, pa je potrebno da o tome obavestite Vašeg lekara ili farmaceuta.